The first time Pavano led the league was in 2009. He spent most of the season with Cleveland before being traded to Minnesota in August. He gave up a combined 113 Earned Runs to lead the American League, narrowly edging out Baltimore pitcher Mark Guthrie's 112. Braden Looper of St. Louis led the National League and tied Pavano for the Major League lead with 113.
Fast forward to 2010, a full season with a better team. Now all of a sudden, Pavano falls out of the top 10 for Earned Runs and manages to tie Cliff Lee for the league lead with 7 Complete Games. You don't throw 7 complete games by giving up a ton of runs so naturally, he tied for the league lead in Shutouts as well. He and Oakland pitcher Dallas Braden each threw 2 shutouts.
Fast forward another year, and Pavano seems to have fallen a little. This time, he's back in the top 10 for Earned Runs at #5 after breaking 100 again. However, now he's leading the league in Hits with 262, thirty two more than the second place finisher CC Sabathia and eighteen more than National League leader Ricky Nolasco.
Pavano missed most of 2012 with a strained shoulder and is currently a free agent. So if he finds a team to sign him and somehow gets a 2013 Topps card, it won't show him leading the league in anything from the most recent season.